Mass-and-volume conversions that come up at the bench. For why the math works, see Syringe, Draw and Dosage Math. For per-vial reconstitution math, see Reconstitution Cheat Sheet. For an interactive version, the peptide calculator handles arbitrary vial / volume / dose combinations.
Mass: mcg, mg, IU
| Unit | Equivalent | Where it shows up |
|---|---|---|
| 1 mg | 1000 mcg | Vial labels (e.g., "5 mg vial"); peptide reference doses. |
| 1 mcg | 0.001 mg | Per-dose ranges for most peptides (Ipamorelin 100 mcg, BPC-157 250 mcg). |
| 1 g | 1000 mg = 1,000,000 mcg | Bulk reagent quantities; not used for individual peptide dosing. |
Volume: mL, units (U), drops
| Unit | Equivalent | Where it shows up |
|---|---|---|
| 1 mL | 100 U on a U-100 insulin syringe | Standard insulin-syringe convention; 1 mL of solution = 100 unit marks. |
| 1 U | 0.01 mL | The smallest reliable mark on a U-100 insulin syringe. |
| 1 mL | ~20 drops (standard dropper) | Intranasal sprays - manufacturer-specific; check the label. |
Reading insulin-syringe units: each numbered mark is 5 U on most U-100 syringes; each minor tick is 1 U. The plunger's leading edge against the mark is what counts, not the trailing edge of the rubber stopper. Eye level on a flat surface, not at an angle.
The HGH IU-vs-mg gotcha
IU (International Units) is a potency measure, not a mass measure. For most peptides this distinction is irrelevant - they're labelled in mcg or mg. For somatropin (recombinant human GH), the convention is mixed and the conversion matters:
| Somatropin | Equivalent | Note |
|---|---|---|
| 1 IU | ~0.33 mg (333 mcg) | The WHO-defined ratio for rhGH (3 IU = 1 mg). |
| 3 IU | 1 mg | Common bodybuilding dose unit - 2β3 IU/day = 0.67β1 mg/day. |
| 5 IU | ~1.67 mg | Higher-end recreational dosing. |
| 10 IU | ~3.33 mg | Per-vial common pack size (10 IU = ~3.33 mg per vial). |
Why this matters: a "10 IU vial" of HGH is a 3.33 mg vial. Reconstitute with 1 mL BAC water and you get 10 IU per mL = 0.1 IU per insulin-syringe unit. A 2 IU dose is 20 units on the syringe.
Common per-dose conversions (worked examples)
| Dose | Vial / recon | Unit marks |
|---|---|---|
| 100 mcg Ipamorelin | 2 mg vial in 2 mL β 10 mcg/U | 10 U |
| 250 mcg BPC-157 | 5 mg vial in 2 mL β 25 mcg/U | 10 U |
| 500 mcg TB-500 | 5 mg vial in 5 mL β 10 mcg/U | 50 U |
| 1.75 mg PT-141 | 10 mg vial in 2 mL β 50 mcg/U | 35 U |
| 2 IU somatropin | 10 IU vial in 1 mL β 0.1 IU/U | 20 U |
Common mistakes
- Reading mL when the syringe is in U. A "1 mL" insulin syringe is graduated to 100 U, not 100 mL. The numbered marks are units. Read what's printed.
- Confusing IU with mcg for non-HGH peptides. Outside of HGH and a couple of approved drugs (insulin), peptides are dosed in mcg or mg. "100 IU of BPC-157" is a category error - there's no IU definition for it.
- Using HGH's 3:1 IU-mg ratio for other peptides. The ratio is specific to rhGH. Other peptides where IU sometimes appears on labels (insulin, oxytocin) have different ratios. When in doubt, use the mcg / mg labelling on the vial.
- Counting from the wrong end of the plunger. Leading edge against the unit mark, not trailing edge. The black rubber stopper has a small bevel; the leading edge is the flat side closest to the needle.
Cross-references
- Syringe, Draw and Dosage Math - the deeper article behind these conversions.
- Reconstitution Cheat Sheet - the per-vial reconstitution math reference.
- Peptide calculator - interactive dose / volume / concentration tool.